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Eur J Cardiovasc Prev Rehabil

Causes and Risk Factors Most Common Cause: Cigarette smoking (primary) Other Risk Factors: Biomass fuel exposure Air pollution Occupational dust/fumes Recurrent lung infections Aging Genetic Cause: Alpha-1 Antitrypsin deficiency (early-onset emphysema, especially in non-smokers) Pathophysiology (Simplified) Smoking or irritants inflammation elastase and proteases Loss of elastic recoil and destruction of alveolar walls Enlarged airspaces gas exchange surface Air trapping hyperinflation Types of Emphysema (based on lobes affected) 1

Over the years the Smoking Man, as he is popularly known like the devil, he goes by many names ruthlessly managed the shows main alien conspiracy, sacrificing his wife to extraterrestrial experiments, shooting his own son and repeatedly thwarting Agent Mulder, the shows hero, who, in a Vaderesque twist, was later revealed to be the Smoking Mans biological son